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The second step in FASTA is to narrow down the high similarity regions between the two sequences.

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The second step in FASTA is to narrow down the high similarity regions between the two sequences.

(a) True

(b) False

The question was posed to me in an interview.

This key question is from FASTA in division Database Similarity Searching of Bioinformatics

1 Answer

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Best answer
Right option is (a) True

To explain I would say: Normally, many diagonals between the two sequences can be identified in the hashing step. The top ten regions with the highest density of diagonals are identified as high similarity regions. The diagonals in these regions are scored using a substitution matrix.

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