Question

If a good sampling of sequences is _______ the number of sequences is _________ and the motif structure is ________ it should, in principle, be possible to obtain frequencies highly representative of the same motif in other sequences also.

(a) available, sufficiently large, not too complex

(b) unavailable, sufficiently large, not too complex

(c) unavailable, sufficiently small, not too complex

(d) available, sufficiently large, too complex

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This question is from Position in chapter Multiple Sequence Alignment of Bioinformatics

Answer 1

The correct option is (a) available, sufficiently large, not too complex

To elaborate: The more abundant amino acids already found in that column would probably be favored. Thus, if a good sampling of sequences is available, the number of sequences is sufficiently large, and the motif structure is not too complex, it should, in principle, be possible to obtain frequencies highly representative of the same motif in other sequences also (Henikoff and Henikoff 1996).