Question

The major drawback of the progressive and iterative alignment strategies is that they are largely global alignment based and may therefore fail to recognize conserved domains and motifs among highly divergent sequences of varying lengths.

(a) True

(b) False

I got this question in homework.

This key question is from Heuristic Algorithms topic in chapter Multiple Sequence Alignment of Bioinformatics

Answer 1

Right option is (a) True

Best explanation: For such divergent sequences that share only regional similarities, a local alignment based approach has to be used. The strategy identifies a block of ungapped alignment shared by all the sequences, hence, the block-based local alignment strategy.