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‘Epidermolysis bullosa simplex’ is caused by the deficiency of ____________ polypeptide.

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‘Epidermolysis bullosa simplex’ is caused by the deficiency of ____________ polypeptide.

(a) myosin

(b) keratin

(c) kinesin

(d) niacin

The question was posed to me in an interview for internship.

I need to ask this question from Cytoskeleton topic in chapter Cytoskeleton and Cell Motility of Cell Biology

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Correct choice is (b) keratin

For explanation I would say: ‘Epidermolysis bullosa simplex’ is a genetic disorder that associated with extremely fragile skin that blisters easily. The disease is caused by mutations in the gene encoding K14, a type I keratin polypeptide.

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