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Proteins can interact with a DNA molecule by ____________________

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Proteins can interact with a DNA molecule by ____________________

(a) fitting into the grooves

(b) interacting with the base pairs

(c) hydrophilic interactions

(d) covalent linkages

This question was posed to me in an international level competition.

My question is taken from Gene Chemical Nature in section Nature of Genome of Cell Biology

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The correct choice is (a) fitting into the grooves

The explanation is: Proteins have domains that fit into major and minor grooves of the DNA molecule. A protein interacting with the DNA in this way can read the sequence of nucleotides without having to separate the strands.

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