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Supercoiled DNA is more compact than its relaxed counterpart and therefore __________

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Supercoiled DNA is more compact than its relaxed counterpart and therefore __________

(a) has lower pH value

(b) sediments faster

(c) sediments slower

(d) denatures quickly

This question was addressed to me during a job interview.

Question is from Gene Chemical Nature topic in chapter Nature of Genome of Cell Biology

1 Answer

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The correct option is (b) sediments faster

Easy explanation: Supercoiled DNA is the molecule twisted upon itself. It is more compact than the relaxed counterpart and occupies lesser volume. Consequently the supercoiled DNA moves rapidly in response to centrifugal or electric fields.

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