Question

Which of the following is untrue about homology modeling?

(a) Homology modeling predicts protein structures based on sequence homology with known structures

(b) It is also known as comparative modeling

(c) The principle behind it is that if two proteins share a high enough sequence similarity, they are likely to have very similar three-dimensional structures

(d) It doesn’t involve the evolutionary distances anywhere

I had been asked this question at a job interview.

Enquiry is from Ab Initio Protein Structural Prediction & Homology Modeling in chapter Protein Tertiary Structure Prediction of Bioinformatics

Answer 1

The correct option is (d) It doesn’t involve the evolutionary distances anywhere

The explanation: As the name suggests, homology modeling predicts protein structures based on sequence homology with known structures. Homology modeling produces an all-atom model based on alignment with template proteins.