Question

Which of the following is untrue regarding TMHMM?

(a) It is a web-based program based on an HMM algorithm

(b) It is trained to recognize transmembrane helical patterns

(c) It is not trained to recognize transmembrane helical patterns

(d) When a query sequence is scanned, the probability of having an α-helical domain is given

This question was posed to me by my school teacher while I was bunking the class.

I'd like to ask this question from Secondary Structure Prediction for Transmembrane Proteins in portion Secondary Structure Prediction of Bioinformatics

Answer 1

The correct option is (c) It is not trained to recognize transmembrane helical patterns

For explanation: It is trained to recognize transmembrane helical patterns based on a training set of 160 well-characterized helical membrane proteins. The orientation of the α-helices is predicted based on the positive-inside rule. The prediction output returns the number of transmembrane helices, the boundaries of the helices, and a graphical representation of the helices. This program can also be used to simply distinguish between globular proteins and membrane proteins.