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Originally, the FOLD program of _____ predicted _____ having the minimum free energy.

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Originally, the FOLD program of _____ predicted _____ having the minimum free energy.

(a) M. Zuker, two structures

(b) M. Wunsch, two structures

(c) M. Zuker, only one

(d) M. Wunsch, only one

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This interesting question is from MFOLD and the Use of Energy Plots in portion RNA Structure Prediction of Bioinformatics

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The correct option is (c) M. Zuker, only one

Explanation: However, changes in a single nucleotide can result in drastic changes in the predicted structure. A later version, called MFOLD, has improved prediction of non-base paired interactions and predicts several structures having energies close to the minimum free energy.

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