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A type of RNA secondary structure prediction method takes into account conserved patterns of base-pairing that are conserved during evolution of a given class of RNA molecules.

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A type of RNA secondary structure prediction method takes into account conserved patterns of base-pairing that are conserved during evolution of a given class of RNA molecules.

(a) True

(b) False

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The doubt is from Limitations of Prediction topic in portion RNA Structure Prediction of Bioinformatics

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The correct answer is (a) True

For explanation: Sequence positions that base-pair are found to vary at the same time during evolution of RNA molecules so that structural integrity is maintained. For example, if two positions G and C form a base pair in a given type of molecule, then sequences that have C and G reversed, or A and U or U and A at the corresponding positions, would be considered reasonable matches.

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