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Which types of changes participate in the process of natural selection?

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Which types of changes participate in the process of natural selection?

(a) nonsynonymous

(b) phenotypic

(c) allotypic

(d) synonymous

I had been asked this question in an international level competition.

This interesting question is from Gene Expression topic in chapter Gene Expression of Cell Biology

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Right option is (a) nonsynonymous

To explain I would say: Nonsynomous are the changes that cause a change in the amino acid sequence when there is a change in the nucleotide sequence. Such changes affect the phenotype of an individual and are hence selected for or against in the process of natural selection.

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