Question

To find suboptimal structures, the dynamic programming method was modified.

(a) True

(b) False

I have been asked this question at a job interview.

Question is from MFOLD and the Use of Energy Plots topic in division RNA Structure Prediction of Bioinformatics

Answer 1

The correct answer is:

(a) True

To find suboptimal structures, the dynamic programming method was indeed modified. This modification allows the identification of RNA secondary structures that are close to the minimum free energy (MFE) structure but with slightly higher free energies. These suboptimal structures are important in understanding the full range of possible RNA conformations and their biological relevance.