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What are the effects of increased concentration of citrate?

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What are the effects of increased concentration of citrate?

(a) Increases the inhibitory effect of ATP

(b) Decreases the inhibitory effect of ATP

(c) Increases the activity of ATP

(d) Increases the activity of AMP

I had been asked this question in my homework.

This interesting question is from Coordinated Regulation of Glycolysis and Gluconeogenesis topic in portion Principles of Metabolic Regulation: Glucose and Glycogen of Biochemistry

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Correct answer is (a) Increases the inhibitory effect of ATP

To elaborate: Citrate is a key intermediate in the aerobic oxidation of pyruvate, fatty acids and amino acids. It serves as an allosteric regulator of PFK-1; its high concentration increases the inhibitory effect of ATP, further reducing the flow of glucose through glycolysis.

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