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Which of the following statements is true about PFK-1?

(a) It is stimulated by AMP and ADP

(b) It is stimulated by citrate and ATP

(c) It is inhibited by AMP and ADP

(d) It is stimulated by citrate and ADP

The question was asked in an interview.

I want to ask this question from Coordinated Regulation of Glycolysis and Gluconeogenesis in chapter Principles of Metabolic Regulation: Glucose and Glycogen of Biochemistry

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Correct choice is (a) It is stimulated by AMP and ADP

Easiest explanation: AMP promotes glycogen degradation and glycolysis by activating glycogen phosphorylase and stimulating the activity of phosphofructokinase-1. ATP and citrate are allosteric inhibitors.

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