Question

Which of the following process occurs between DNA molecules of very similar sequences?

(a) Homologous genetic recombination

(b) Site specific recombination

(c) Non-homologous recombination

(d) Replicative recombination

The question was asked in final exam.

Question is taken from DNA Recombination topic in portion DNA, RNA and Protein Metabolism of Biochemistry

Answer 1

The correct answer is:

(a) Homologous genetic recombination

Explanation: Homologous genetic recombination occurs between DNA molecules that have very similar or identical sequences. This process involves the exchange of genetic material between two similar or identical DNA molecules, typically during meiosis or in processes like DNA repair.

• Site-specific recombination (b) is a process where recombination occurs at specific, predetermined sequences in the genome, often involving the integration of viral DNA or transposons.
• Non-homologous recombination (c) involves recombination between DNA sequences that are not similar or homologous, often leading to insertions or deletions.
• Replicative recombination (d) refers to a type of recombination associated with DNA replication and is not specifically related to the similarity of the sequences involved.

Thus, the process that occurs between DNA molecules of very similar sequences is homologous genetic recombination.