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Posttranslational modification of many eukaryotic proteins begins in the ____________

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Posttranslational modification of many eukaryotic proteins begins in the ____________

(a) Endoplasmic reticulum

(b) Mitochondria

(c) Chloroplasts

(d) Nucleus

The question was posed to me in final exam.

This key question is from Protein Targeting and Degradation in section DNA, RNA and Protein Metabolism of Biochemistry

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Right option is (a) Endoplasmic reticulum

To explain: Most lysosomal, membrane or secreted proteins have an amino-terminal signal sequence that marks them for translocation into the lumen of the ER.

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