Question

Nuclear localization signal is rich in ____________

(a) Tryptophan and histidine

(b) Serine and threonine

(c) Glutamine and asparagine

(d) Lysine and arginine

I got this question during an interview.

I'd like to ask this question from Protein Targeting and Degradation in portion DNA, RNA and Protein Metabolism of Biochemistry

Answer 1

The correct answer is:

(d) Lysine and arginine

A Nuclear Localization Signal (NLS) is typically rich in lysine and arginine residues. These positively charged amino acids facilitate the transport of proteins into the nucleus by interacting with nuclear import receptors.