Question

Globular proteins are usually insoluble.

(a) True

(b) False

This question was addressed to me by my school principal while I was bunking the class.

My question is based upon Protein Structure Basics topic in section Structural Bioinformatics of Bioinformatics

Answer 1

Right option is (b) False

Explanation: Globular proteins are usually soluble and surrounded by water molecules. They tend to have an overall compact structure of spherical shape with polar or hydrophilic residues on the surface and hydrophobic residues in the core. Such an arrangement is energetically favorable because it minimizes contacts with water by hydrophobic residues in the core and maximizes interactions with water by surface polar and charged residues. Common examples of globular proteins are enzymes, myoglobins, cytokines, and protein hormones.