Question

Which of the following is wrong statement about DNAML and DNAMLK?

(a) PHYLIP includes mentioned two programs for this maximum likelihood analysis

(b) DNAML estimates phylogenies from nucleotide sequences by the maximum likelihood method

(c) DNAMLK estimates phylogenies in the same manner as DNAML

(d) DNAMLK estimates phylogenies without molecular clock

I have been asked this question in an interview for internship.

The above asked question is from The Maximum Likelihood Approach topic in chapter Phylogenetic Tree Construction Methods and Programs of Bioinformatics

Answer 1

Right answer is (d) DNAMLK estimates phylogenies without molecular clock

Explanation: DNAMLK estimates phylogenies from nucleotide sequences by the maximum likelihood method in the same manner as DNAML, but assumes a molecular clock. DNAML allows for variable frequencies of the four nucleotides, for unequal rates of transitions and transversions, and for different rates of change in different categories of sites, as specified by the program.