Question

Which of the following wrong about HMM GENE?

(a) It is also an HMM-based web program

(b) It uses a criterion called the conditional maximum likelihood to discriminate coding from non-coding features

(c) HMM prediction is unbiased toward the locked region

(d) If a sequence already has a sub-region identified as coding region, which may be based on similarity with cDNAs or proteins in a database, these regions are locked as coding regions

I got this question in an interview.

The query is from Gene Prediction in Eukaryotes in division Gene and Promoter Prediction of Bioinformatics

Answer 1

The correct choice is (c) HMM prediction is unbiased toward the locked region

Best explanation: An HMM prediction is subsequently made with a bias toward the locked region and is extended from the locked region to predict the rest of the gene coding regions and even neighboring genes. The program is in a way a hybrid algorithm that uses both ab initio-based and homology-based criteria.