Question

In Ab Initio–Based Programs for Gene Prediction– Gene content refers to coding statistics, which includes nonrandom nucleotide distribution, amino acid distribution, synonymous codon usage, and hexamer frequencies.

(a) True

(b) False

This question was addressed to me by my college professor while I was bunking the class.

This key question is from Gene Prediction in Eukaryotes in division Gene and Promoter Prediction of Bioinformatics

Answer 1

Right option is (a) True

Easy explanation: Among these features, the hexamer frequencies appear to be most discriminative for coding potentials. To derive an assessment for this feature, HMMscan be used, which require proper training. In addition to HMMs, neural network-based algorithms are also common in the gene prediction field.