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Neighbor-joining chooses the sequences that should be joined to give the best least squares estimates of the branch lengths that most closely reflect the actual distances between the sequences.

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Neighbor-joining chooses the sequences that should be joined to give the best least squares estimates of the branch lengths that most closely reflect the actual distances between the sequences.

(a) True

(b) False

I got this question in examination.

Question is taken from Maximum Parsimony Method in division Phylogenetic Tree Construction Methods and Programs of Bioinformatics

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Correct choice is (a) True

The explanation: It is not necessary to compare all possible trees to find the least squares fit as in the Fitch-Margoliash method. The method pairs sequences based on the effect of the pairing on the sum of the branch lengths of the tree.

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