Question

Eukaryotic RNA polymerase II does not directly bind to the promoter, but relies on a dozen or more transcription factors to recognize and bind to the promoter in a specific order before its own binding around the promoter.

(a) True

(b) False

This question was addressed to me in examination.

My enquiry is from Promoter and Regulatory Elements in Prokaryotes & Eukaryotes topic in section Promoter and Regulatory Element Prediction of Bioinformatics

Answer 1

The correct answer is (a) True

Best explanation: The core of many eukaryotic promoters is a so-called TATA box, located 30 bps upstream from the transcription start site, having a consensus motif TATA (A/T) A (A/T). However, not all eukaryotic promoters contain the TATA box. Many genes such as housekeeping genes do not have the TATA box in their promoters.