Question

The disadvantage of Multiple conformation rigid-body method is that the active conformation may be missed as the result of a minor structural difference not considered in the ______ ligand conformations. Where, the N is the number of low-energy conformations.

(a) N +1

(b) N

(c) N^2

(d) N/2

This question was posed to me in semester exam.

The origin of the question is Conformational Flexibility topic in division Predicting the Structure of Protein – Biomolecular Interactions of Bioinformatics

Answer 1

The correct choice is (b) N

For explanation I would say: The disadvantage is that the active conformation may be missed as the result of a minor structural difference not considered in the N ligand conformations and the advantage of this approach is that the search can be restricted to a smaller number of relevant ligand conformations.