Question

In Multiple conformation rigid-body method, a ligand is assumed to be able to adopt a number (N) of different _______ that are computed _____ the ligand being docked into the receptor.

(a) low-energy conformations, after

(b) low-energy conformations, prior to

(c) high-energy conformations, prior to

(d) high-energy conformations, after

The question was posed to me by my school teacher while I was bunking the class.

I'm obligated to ask this question of Conformational Flexibility topic in section Predicting the Structure of Protein – Biomolecular Interactions of Bioinformatics

Answer 1

Correct answer is (b) low-energy conformations, prior to

Explanation: These, N, low-energy conformations are then docked individually into the receptor assuming a rigid conformation using a descriptor-based approach. The scoring function is used to determine which of the resulting solutions is optimal.