Question

To increase the specificity of prediction, a unique feature of eukaryotic promoter is employed, which is the presence of CpG islands.

(a) True

(b) False

This question was addressed to me by my college professor while I was bunking the class.

My question is based upon Prediction Algorithms in division Promoter and Regulatory Element Prediction of Bioinformatics

Answer 1

Correct choice is (a) True

For explanation I would say: It is known that many vertebrate genes are characterized by a high density of CG dinucleotides near the promoter region overlapping the transcription start site. By identifying the CpG islands, promoters can be traced on the immediate upstream region from the islands. By combining CpG islands and other promoter signals, the accuracy of prediction can be improved. Several programs have been developed based on the combined features to predict the transcription start sites in particular.