Question

To improve the specificity of prediction, some algorithms selectively ______ coding regions and focus on the upstream regions________ which are most likely to contain promoters. In that sense, promoter prediction and gene prediction are coupled.

(a) include, (0.5 to 2.0 kb) only

(b) include, (0.5 to 2.0 Mb) only

(c) exclude, (0.5 to 2.0 Mb) only

(d) exclude, (0.5 to 2.0 kb) only

I had been asked this question by my school teacher while I was bunking the class.

This key question is from Prediction Algorithms topic in section Promoter and Regulatory Element Prediction of Bioinformatics

Answer 1

The correct answer is (d) exclude, (0.5 to 2.0 kb) only

To explain I would say: To better discriminate true motifs from background noise, a new generation of algorithms has been developed that take into account the higher order correlation of multiple subtle features by using discriminant functions, neural networks, or hidden Markov models (HMMs) that are capable of incorporating more neighboring sequence information.