Question

There was little degree of success in docking an antibody-antigen complex in the second challenge for the protein-protein docking evaluation.

(a) True

(b) False

I have been asked this question in homework.

I'd like to ask this question from Evaluation of Models & Visualization Methods in division Predicting the Structure of Protein – Biomolecular Interactions of Bioinformatics

Answer 1

Correct option is (a) True

To explain I would say: This may be because modeling molecular recognition is in general more difficult in antibody-antigen than protein-inhibitor systems. In the protein-ligand docking challenge at CASP2 there was generally a good level of success, however, again certain targets proved to be problematic.