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The division of retrovirus is limited in invivo condition.

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The division of retrovirus is limited in invivo condition.

(a) True

(b) False

The question was posed to me during a job interview.

Query is from Gene Therapy Using Viral Vectors topic in portion Utilizing Genetically Engineered Organisms & Medical Applications of Bioprocess Engineering of Bioprocess Engineering

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Correct option is (a) True

The best I can explain: The resulting retrovirus vector can be used only with dividing cells, since cells must undergo mitosis before gene integration can occur. This feature limits in vivo use to cases such as cancer suppression but is not a limitation on ex vivo systems.

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