Question

What is the pH of late endosomes?

(a) 3.0

(b) 4.5

(c) 6.0

(d) 7.5

The question was posed to me during an interview.

I'd like to ask this question from Gene Therapy Using Viral Vectors topic in section Utilizing Genetically Engineered Organisms & Medical Applications of Bioprocess Engineering of Bioprocess Engineering

Answer 1

Correct choice is (b) 4.5

Easiest explanation: The intravesicular pH drops along the endocytic pathway, from pH 4.5–5.5 in late endosomes and lysosomes.