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In relation to surface area roller bottles are less advantageous than T-Flask.

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In relation to surface area roller bottles are less advantageous than T-Flask.

(a) True

(b) False

This question was posed to me in an interview.

This intriguing question comes from Bioreactor Considerations topic in portion Bioprocess Considerations in Using Animal Cell Cultures of Bioprocess Engineering

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Right answer is (b) False

Best explanation: The roller-bottle system has an advantage over T-flasks because of increased surface area, agitation of the liquid, and better aeration. Roller bottles are not typically used for large-scale production because of high labor requirements and bottle-to-bottle variability.

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