Question

Small bubbles are more shear sensitive than large bubbles.

(a) True

(b) False

The question was asked in final exam.

My question is from Methods Used for the Cultivation of Animal Cells in section Bioprocess Considerations in Using Animal Cell Cultures of Bioprocess Engineering

Answer 1

The correct answer is:

(a) True

Small bubbles are indeed more shear sensitive than large bubbles because they have a larger surface area-to-volume ratio, which makes them more susceptible to damage from shear forces in bioreactors. This can affect the efficiency of oxygen transfer and overall cell culture performance.