Question

Arrestins compete with ________________ for binding with G-protein coupled receptors.

(a) Effectors

(b) Primary messengers

(c) Secondary messengers

(d) G-proteins

This question was addressed to me by my college professor while I was bunking the class.

This interesting question is from Cell Signaling and Signal Transduction in division Cell Signaling and Signal Transduction of Cell Biology

Answer 1

Correct choice is (d) G-proteins

Explanation: Arrestins are small group of proteins that bind to the G-protein coupled receptors. To bind to these receptors, the arrestins compete with heterotrimeric G-proteins. In the process of desensitization, arrestin binding prevents further activation of the G-proteins.