Question

The inactive conformation of a G-protein coupled receptor is stabilized by ____________________

(a) covalent interactions

(b) hydrogen binding

(c) non-covalent interactions

(d) ionic interactions

I got this question by my school teacher while I was bunking the class.

My question is taken from Cell Signaling and Signal Transduction in portion Cell Signaling and Signal Transduction of Cell Biology

Answer 1

Right option is (c) non-covalent interactions

For explanation: The inactive conformation of the G-protein coupled receptor is stabilized by non-covalent interactions between the residues in the transmembrane alpha helices. Rotation or movements in these loops cause changes in the conformation of cytoplasmic loops.