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Etoposide and doxorubicin, the drugs used in Cancer treatment target the enzyme ___________

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Etoposide and doxorubicin, the drugs used in Cancer treatment target the enzyme ___________

(a) topoisomerase I

(b) topoisomerase II

(c) helicase

(d) isomerase

The question was posed to me during an online exam.

This is a very interesting question from Genome Structure topic in portion Nature of Genome of Cell Biology

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Right option is (b) topoisomerase II

Easy explanation: Both these drugs are target DNA in Cancer cells. They bind to topoisomerase II enzyme which prevents the DNA stands from re-ligating and thus causes it to break.

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