Question

A change in nucleotide sequence that does not affect the amino acid sequence is called _____________ change.

(a) insignificant

(b) significant

(c) synonymous

(d) nonsynonymous

The question was asked during an interview for a job.

I want to ask this question from Gene Expression in portion Gene Expression of Cell Biology

Answer 1

Correct choice is (c) synonymous

To elaborate: Changes in the genome occur throughout the evolution and among all the species. A change in the nucleotide sequence of the gene that does not affect the amino acid sequence of the polypeptide is called a synonymous change.