Question

Which of the following does not converge to activate the same signaling pathway?

(a) G-protein coupled receptor

(b) Receptor tyrosine kinase

(c) Integrin

(d) Calmodulin

I got this question in an interview for internship.

The doubt is from Cell Signaling and Signal Transduction in section Cell Signaling and Signal Transduction of Cell Biology

Answer 1

Right option is (d) Calmodulin

Easiest explanation: The three types of cell surface receptors – G-protein coupled receptors, receptor tyrosine kinases and integrins, all can converge to lead to the formation of phosphotyrosine docking sites for the SH2 domain of the adaptor protein Grb2 in close proximity to the plasma membrane.