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The last proteins to involve in the apoptotic pathway induced by TNF are ______________________

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The last proteins to involve in the apoptotic pathway induced by TNF are ______________________

(a) caspase-2

(b) procaspase-2

(c) caspase-8

(d) procaspase-8

I had been asked this question in exam.

Enquiry is from Cell Signaling and Signal Transduction topic in section Cell Signaling and Signal Transduction of Cell Biology

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The correct choice is (d) procaspase-8

For explanation I would say: The last proteins that get involved in the apoptotic pathway triggered by the tumor necrosis factor are procaspases-8 – the precursors of caspase proteins. Procaspases contain an extra portion that must be removed by catalytic action.

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