Question

Cyclin binding leads to a change in the _________________ of kinase.

(a) pH

(b) temperature

(c) concentration

(d) conformation

I got this question in an interview.

The doubt is from Cellular Reproduction in chapter DNA Replication and Repair, Cellular Reproduction of Cell Biology

Answer 1

Right answer is (d) conformation

To explain I would say: Cyclin binding leads to a change in the conformation of catalytic subunit of kinase enzyme by binding to its catalytic site. This binding allows the cyclin dependent kinase (CDK) to phosphorylate its substrates.