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Viagra is specific for which isoform of cGMP phosphodiesterase?

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Viagra is specific for which isoform of cGMP phosphodiesterase?

(a) PDE2

(b) PDE4

(c) PDE5

(d) PDE8

I had been asked this question by my college professor while I was bunking the class.

My enquiry is from Cell Signaling and Signal Transduction topic in section Cell Signaling and Signal Transduction of Cell Biology

1 Answer

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Best answer
Right option is (c) PDE5

Easiest explanation: Cyclic guanosine monophosphate (cGMP) phosphodiesterase is the enzyme that destroys cyclic guanosine monophosphate. Viagra inhibits the particular isoform PDE5 of the enzyme.

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