Question

IgG is the predominant antibody in the secretion of respiratory tract.

(a) True

(b) False

The question was posed to me in a job interview.

My question comes from Molecular Basis of Immunity in chapter Immune Response of Cell Biology

Answer 1

The correct answer is:

(b) False

Explanation:

IgA, not IgG, is the predominant antibody found in the secretions of the respiratory tract. IgA plays a critical role in mucosal immunity, particularly in the protection of mucosal surfaces such as the respiratory and gastrointestinal tracts. It is primarily secreted in mucosal areas in the form of secretory IgA (sIgA).

IgG, on the other hand, is the most abundant antibody in the bloodstream and plays a key role in systemic immunity, but it is not the predominant antibody in mucosal secretions like those in the respiratory tract.

Correct Answer: (b) False