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Class-switching of antibodies can occur by changing the ___________________

(a) heavy chain

(b) light chain

(c) pH

(d) temperature

This question was addressed to me by my college director while I was bunking the class.

My question is from Molecular Basis of Immunity topic in chapter Immune Response of Cell Biology

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The correct option is (a) heavy chain

Easy explanation: The class-switching of antibodies can take place by changing the heavy chains of immunoglobulins without make any change to the antigen binding region. B cells can change the antibodies they make even after producing them.

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