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Which of these mutations will have the least harmful effect?

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Which of these mutations will have the least harmful effect?

(a) Addition of 2 bases

(b) Deletion of 3 bases

(c) Transition of one base

(d) Deletion of a chunk

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The correct choice is (c) Transition of one base

For explanation I would say: In all possibilities transition of a base would have least harmful effect as there are degenerate codons for same amino acid. The new codon could thus be a silent mutation. Also if it is the 3rd base due to wooble hypothesis it will have negligible effect.

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