Question

Transposition doesn’t require much sequence homology between two genetic molecules, based on this hey can help in _____________

(a) Homologous DSB repair

(b) Non-homologous end joining

(c) Site-specific recombination

(d) Homologous recombination

The question was posed to me during an interview for a job.

This intriguing question comes from Chromosomal Abnormalities : Translocation in portion Chromosomal Basis of Inheritance of Cytogenetics

Answer 1

Correct answer is (c) Site-specific recombination

To elaborate: In case of site specific recombination there would be very little or no homology between the donor and recipient site, this can be imposed by translocation. Translocation doesn’t play a part in homologous repair or NHEJ.