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Which of the following is done by HCR?

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Which of the following is done by HCR?

(a) Phosphorylation of eIF4E-BP

(b) Phosphorylation of eIF2-alpha

(c) Dephosphorylation of eIF4E-BP

(d) Dephosphorylation of eIF2-Alpha

The question was posed to me in my homework.

My question is based upon Initiation in portion Gene Expression : Translation of Cytogenetics

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Best answer
Correct option is (b) Phosphorylation of eIF2-alpha

The best explanation: HCR is Heme Controlled Repressor protein which senses the lack of heme in the medium and phosphorylated eIF2-alpha. This prevents the GEF activity of eIF2B and prevents translation. This measure prevents the waste of resources.

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