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What is the most important characteristic of a drug to be absorbed after oral administration?

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What is the most important characteristic of a drug to be absorbed after oral administration?

(a) Dissolved in HCL

(b) Dissolved in alkaline solution

(c) Can pass through the cell membrane

(d) Form aggregate and settle down

I got this question in a national level competition.

Enquiry is from Gastrointestinal Absorption of Drugs topic in division Absorption of Drugs of Drug Biotechnology

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The correct option is (c) Can pass through the cell membrane

Explanation: A drug should not get destroyed by either of acidic or alkaline medium. It must first pass through the biological barrier of cell membrane. Formation of aggregation will decrease its molecular activity.

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