Question

Which one of the following is a critical rate-limiting step of drug absorption?

(a) Rate of drug disintegration

(b) Size of the drug

(c) Size of the porous particle

(d) Rate of dissolution

The question was posed to me during an interview for a job.

Query is from Physicochemical Factors Affecting Drug Absorption in portion Absorption of Drugs of Drug Biotechnology

Answer 1

Right option is (d) Rate of dissolution

To explain I would say: For orally administered drug, the two critically slower rate determining step is the rate of dissolution and the rate of drug permeation. Dissolution is the rate determining stem for poorly aqueous soluble drugs and hydrophobic drugs.