Question

Chromosome ____________ trisomy leads to Edward’s syndrome.

(a) 12

(b) 13

(c) 18

(d) 21

This question was addressed to me during an interview.

Origin of the question is Chromosomal Abnormalities : Aneuploidy topic in chapter Chromosomal Basis of Inheritance of Cytogenetics

Answer 1

Right answer is (c) 18

For explanation: Chromosome 18 trisomy will lead to Edward’s syndrome. Trisomy in chromosome 13 and 21 leads to Patau and Down’s syndrome respectively.