Question

The probability of aneuploidy in offspring increases with age as _________________

(a) Chromosomes tend to lose information with age

(b) Pairings at dichtyotene stages are gradually lost

(c) Ability of fertilization with age is gradually lost

(d) Chromosomal aberration with age

I had been asked this question in class test.

My question comes from Chromosomal Abnormalities : Aneuploidy topic in section Chromosomal Basis of Inheritance of Cytogenetics

Answer 1

Correct choice is (b) Pairings at dichtyotene stages are gradually lost

The explanation: The chromosomes with age tend to lose the proper pairings that existed when they were in dictyotene stage as this is prolonged over decades. This leads to improper segregation causing trisomy.