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What is a negative regulator of Cdc-20?

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What is a negative regulator of Cdc-20?

(a) M-Cdk

(b) Mad-2

(c) Mdm

(d) Hct1

This question was posed to me during a job interview.

My doubt stems from Overview of Cell Reproduction in chapter Chromosomal Changes During Meiosis of Cytogenetics

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Best answer
Correct answer is (b) Mad-2

The best explanation: Mad 2 bind to unbound kinetochores, which leads to inactivation of Cdc-20. This is a checkpoint that makes sure anaphase only occurs when all the centromeres are bound to spindle. M-Cdk and hct1 promote activity, while Mdm is not directly linked to its activity.

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